AZITHROMYCIN 500MG
It’s widely used to treat chest infections such as pneumonia, infections of the nose and throat such as sinus infection (sinusitis), skin infections, Lyme disease, and some sexually transmitted infections.
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Azithromycin is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria. This medication will not work for viral infections (such as common cold, flu).
Oral
Chancroid, Uncomplicated genital infections due to Chlamydia trachomatis
Adult: 1 g as a single dose.
Oral
Prophylaxis of disseminated Mycobacterium avium complex (MAC) infections
Adult: 1.2 g once weekly.
Oral
Acute otitis media
Child: ≥6 months As immediate release suspension: 30 mg/kg as a single dose or 10 mg/kg once daily for 3 days or 10 mg/kg as a single dose in day 1, followed by 5 mg/kg/day on days 2-5.
Oral
Acute bacterial sinusitis
Adult: As tab, cap or immediate release suspension: 500 mg once daily for 3 days. As extended release suspension: 2 g as a single dose.
Child: As immediate release suspension: 10 mg/kg once daily for 3 days.
Oral
Respiratory tract infections, Skin and soft tissue infections
Adult: As tab, cap, or immediate release suspension: 500 mg daily for 3 days. Alternatively, 500 mg as single dose on day 1 followed by 250 mg daily on days 2-5.
Child: ≥6 months As immediate release suspension: 10 mg/kg daily for 3 days or 10 mg/kg on day 1, followed by 5 mg/kg/day on days 2-5. >45 kg: Same as adult dose.
Oral
Uncomplicated gonorrhoea
Adult: 1 g or 2 g as a single dose, in combination with ceftriaxone.
Oral
Pharyngitis, Tonsillitis
Child: >2 years As immediate release preparation: 12 mg/kg/day for 5 days.
Oral
Community-acquired pneumonia
Adult: As tab, cap, or immediate release suspension: 500 mg on day 1, followed by 250 mg once daily on days 2-5. As extended release suspension: 2 g as a single dose.
Child: ≥6 months As immediate release suspension: 10 mg/kg as single dose on day 1 followed by 5 mg/kg/day on days 2-5. As extended release suspension: 60 mg/kg as a single dose. Max: 2 g.
Administration
Tab & Susp: May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Cap &Amp; Extended Release Microspheres: Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Reconstitution
Intravenous:
Powder for inj: Add 4.8 mL of sterile water for inj to the 500 mg vial. Further diluted to a concentration of 1 mg/mL (500 mL) to 2 mg/mL (250 mL) in normal saline, 5% dextrose in water or lactated ringer solution.
Contraindications
Hypersensitivity to macrolide antibiotics. History of hepatic dysfunction/cholestatic jaundice following previous antibiotic use.
Special Precautions
Patients with myasthenia gravis, electrolyte disturbance particularly hypokalaemia and hypomagnesaemia; bradycardia, cardiac arrhythmia, severe cardiac insufficiency, congenital or documented QT prolongation, history of torsades de pointes. Severe renal (GFR <10 mL/min) and hepatic impairment. Children. Pregnancy and lactation. Azithromycin should not be given long-term to prevent bronchiolitis obliterans syndrome in patients with cancers of the blood or lymph nodes who undergo a hematopoietic stem cell transplant.